Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 112
Filtrar
1.
Surg Obes Relat Dis ; 19(9): 1049-1057, 2023 09.
Artigo em Inglês | MEDLINE | ID: mdl-36931965

RESUMO

BACKGROUND: Traditional surgical outcomes are measured retrospectively and intermittently, limiting opportunities for early intervention. OBJECTIVES: The objective of this study was to use risk-adjusted cumulative sum (RA-CUSUM) to track perioperative surgical outcomes for laparoscopic gastric bypass. We hypothesized that RA-CUSUM could identify performance variations between surgeons. SETTING: Two mid-Atlantic quaternary care academic centers. METHODS: Patient-level data from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) were abstracted for laparoscopic gastric bypasses performed by 3 surgeons at 2 high-volume centers from 2014 to 2021. Estimated probabilities of serious complications, reoperation, and readmission were derived from the MBSAQIP risk calculator. RA-CUSUM curves were generated to signal observed-to-expected odds ratios (ORs) of 1.5 (poor performance) and .5 (superior performance). Control limits were set based on a false positive rate of 5% (α = .05). RESULTS: We included 1192 patients: Surgeon A = 767, Surgeon B = 188, and Surgeon C = 237. Overall rates of serious complications, 30-day reoperations, and 30-day readmissions were 3.9%, 2.5%, and 5.2% respectively, with expected rates of 4.7%, 2.2%, and 5.8%. RA-CUSUM signaled lower-than-expected (OR < .5) rates of readmission and serious complication in Surgeon A, and higher-than-expected (OR > 1.5) readmission rate in Surgeon C. Surgeon A further demonstrated an early period of higher-than-expected (OR > 1.5) reoperation rate before April 2015, followed by superior performance thereafter (OR < .5). Surgeon B's performance generally reflected expected standards throughout the study period. CONCLUSIONS: RA-CUSUM adjusts for clinical risk factors and identifies performance outliers in real-time. This approach to analyzing surgical outcomes is applicable to quality improvement, root-cause analysis, and surgeon incentivization.


Assuntos
Derivação Gástrica , Laparoscopia , Garantia da Qualidade dos Cuidados de Saúde , Cirurgiões , Desempenho Profissional , Humanos , Derivação Gástrica/efeitos adversos , Derivação Gástrica/métodos , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Resultado do Tratamento , Centros Médicos Acadêmicos , Hospitais com Alto Volume de Atendimentos , Mid-Atlantic Region/epidemiologia , Reoperação/estatística & dados numéricos , Readmissão do Paciente/estatística & dados numéricos , Risco Ajustado , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Garantia da Qualidade dos Cuidados de Saúde/métodos
3.
Am J Emerg Med ; 50: 773-777, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34698640

RESUMO

INTRODUCTION: While the role of palliative care in the emergency department is recognized, barriers against the effective integration of palliative interventions and emergency care remain. We examined the association between goals-of-care and palliative care consultations and healthcare utilization outcomes in older adult patients who presented to the emergency department (ED) with sepsis. METHODS: We performed a retrospective review of 197 patients aged 65 years and older who presented to the ED with sepsis or septic shock. Healthcare utilization outcomes were compared between patients divided into 3 groups: no palliative care consultation, palliative care consultation within 4 days of admission (i.e., early consultation), and palliative care consultation after 4 days of admission (i.e., late consultation). RESULTS: 51% of patients did not receive any palliative consultation, 39% of patients underwent an early palliative care consultation (within 4 days), and 10% of patients underwent a late palliative care consultation (after 4 days). Patients who received late palliative care consultation had a significantly increased number of procedures, total length of stay, ICU length of stay, and cost (p < .01, p < .001, p < .05, p < .001; respectively). Regarding early palliative care consultation, there were no statistically significant associations between this intervention and our outcomes of interest; however, we noted a trend towards decreased total length of stay and decreased healthcare cost. CONCLUSION: In patients aged 65 years and older who presented to the ED with sepsis, early palliative consultations were associated with reduced healthcare utilization as compared to late palliative consultations.


Assuntos
Serviço Hospitalar de Emergência/organização & administração , Utilização de Instalações e Serviços/estatística & dados numéricos , Cuidados Paliativos/organização & administração , Encaminhamento e Consulta/organização & administração , Sepse/terapia , Idoso , Idoso de 80 Anos ou mais , Serviço Hospitalar de Emergência/economia , Utilização de Instalações e Serviços/economia , Feminino , Custos de Cuidados de Saúde/estatística & dados numéricos , Humanos , Tempo de Internação/economia , Tempo de Internação/estatística & dados numéricos , Modelos Lineares , Masculino , Mid-Atlantic Region , Cuidados Paliativos/economia , Cuidados Paliativos/métodos , Planejamento de Assistência ao Paciente , Encaminhamento e Consulta/economia , Estudos Retrospectivos , Fatores de Tempo
4.
Surgery ; 170(5): 1554-1560, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34175115

RESUMO

BACKGROUND: Perforated peptic ulcer is a morbid emergency general surgery condition. Best practices for postoperative care remain undefined. Surgical dogma preaches practices such as peritoneal drain placement, prolonged nil per os, and routine postoperative enteral contrast imaging despite a lack of evidence. We aimed to evaluate the role of postoperative enteral contrast imaging in postoperative perforated peptic ulcer care. Our primary objective was to assess effects of routine postoperative enteral contrast imaging on early detection of clinically significant leaks. METHODS: We conducted a multicenter retrospective cohort study of patients who underwent repair of perforated peptic ulcer between July 2016 and June 2018. We compared outcomes between those who underwent routine postoperative enteral contrast imaging and those who did not. RESULTS: Our analysis included 95 patients who underwent primary/omental patch repair. The mean age was 60 years, and 54% were male. Thirteen (14%) had a leak. Eighty percent of patients had a drain placed. Nine patients had leaks diagnosed based on bilious drain output without routine postoperative enteral contrast imaging. Use of routine postoperative enteral contrast imaging varied significantly between institutions (30%-87%). Two late leaks after initial normal postoperative enteral contrast imaging were confirmed by imaging after a clinical change triggered the second study. Two patients had contained leaks identified by routine postoperative enteral contrast imaging but remained clinically well. Duration of hospital stay was longer in those who received routine postoperative enteral contrast imaging (12 vs 6 days, median; P = .000). CONCLUSION: Routine postoperative enteral contrast imaging after perforated peptic ulcer repair likely does not improve the detection of clinically significant leaks and is associated with increased duration of hospital stay.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/estatística & dados numéricos , Úlcera Péptica Perfurada/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Idoso , Colorado/epidemiologia , Meios de Contraste , Feminino , Humanos , Masculino , Mid-Atlantic Region/epidemiologia , Pessoa de Meia-Idade , Úlcera Péptica Perfurada/diagnóstico por imagem , Complicações Pós-Operatórias/epidemiologia , Radiografia , Estudos Retrospectivos
5.
BMC Complement Med Ther ; 20(1): 323, 2020 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-33109153

RESUMO

BACKGROUND: The usage and attitudes towards medical marijuana in Cystic Fibrosis (CF) patients is unknown. Through the use of a survey we aim to clarify rates and reasons for use. METHODS: An anonymous survey was sent out to six centers in the Mid-Atlantic region of the United States. Use of and reason for medical marijuana was assessed, along with attitudes of the perceived utility of medical marijuana. RESULTS: A total of 637 surveys were sent out, and 193 surveys were returned (30.3% return rate). Three did not give consent, and one was empty, for a total of 189 completed surveys. 31 subjects (16.5%) reported having used marijuana for medical purposes in their lifetime, with 29 (15.4%) of these in the past year. The most used forms were edible and vaporized. The most common indications for usage were pain and stress. 28 out of 31 found marijuana to be a great deal effective for their symptoms. 21 of the 31 rated marijuana very important or important to their health. There were two reported side effects, both mild. Of 156 subjects who responded to the question if they would be interested in medical marijuana if available, 72 (46.2%) replied yes. CONCLUSION: The use of marijuana for medical reasons was 15.4% in the past year in this sample CF population, although more expressed interest if it was available through prescription. Side effects were rare. CF physicians are going to have to familiarize themselves with advantages and disadvantages of medical marijuana as there is a great deal of interest within the community, and legalization becomes more common.


Assuntos
Atitude Frente a Saúde , Fibrose Cística/complicações , Maconha Medicinal/uso terapêutico , Adolescente , Adulto , Criança , Feminino , Humanos , Masculino , Mid-Atlantic Region , Inquéritos e Questionários , Adulto Jovem
6.
Clin Nurse Spec ; 34(5): 208-216, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32796381

RESUMO

PURPOSE/OBJECTIVES: The Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (PCL-5) with Criterion A was universally used in admission screening to pilot a trauma-informed care process for quality improvement. DESCRIPTION OF THE PROJECT: All adult inpatient behavioral health patients at a Mid-Atlantic county hospital were screened for trauma exposure on admission. Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition with Criterion A was provided to all adults admitted to a 27-bed inpatient behavioral health unit for 8 weeks. Quantitative descriptive statistics were calculated based on self-report PCL-5 scores; qualitative data were gathered from staff and stakeholders. OUTCOME: During the pilot period, there was a 49.2% response rate. Fifty respondents (53.8%) screened positive for trauma as recorded on the Criterion A portion. Seventeen (18.3%) were negative for trauma self-report, and 26 (30.0%) did not complete this portion. Fifty-six (60.2%) completed screens scored 33 or greater on the PCL-5 portion. Staff found the timing of administration convenient but expressed concern over emotional cost to patient. CONCLUSIONS: Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition with Criterion A served as guidepost for trauma-informed assessment, treatment, and referrals. Future considerations may include timing of presentation to patient, electronic translation of the tool to facilitate interdisciplinary collaboration, and tracking of screening completion.


Assuntos
Programas de Rastreamento/métodos , Serviços de Saúde Mental/organização & administração , Transtornos de Estresse Pós-Traumáticos/diagnóstico , Transtornos de Estresse Pós-Traumáticos/enfermagem , Adulto , Lista de Checagem , Manual Diagnóstico e Estatístico de Transtornos Mentais , Unidades Hospitalares , Hospitalização , Humanos , Mid-Atlantic Region , Enfermeiros Clínicos , Projetos Piloto , Melhoria de Qualidade
7.
J Surg Oncol ; 122(2): 134-143, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32346886

RESUMO

BACKGROUND AND OBJECTIVES: Many newly diagnosed breast cancer patients do not receive genetic counseling and testing at the time of diagnosis. We examined predictors of genetic testing (GT) in this population. METHODS: Within a randomized controlled trial of proactive rapid genetic counseling and testing vs usual care, patients completed a baseline survey within 6 weeks of breast cancer diagnosis but before a definitive survey. We conducted a multinomial logistic regression to identify predictors of GT timing/uptake. RESULTS: Having discussed GT with a surgeon was a dominant predictor (χ2 (2, N = 320) = 70.13; P < .0001). Among those who discussed GT with a surgeon, patients who had made a final surgery decision were less likely to receive GT before surgery compared with postsurgically (OR [odds ratio] = 0.24; 95% confidence interval [CI] = 0.12-0.49) or no testing (OR = 0.28; 95% CI = 0.14-0.56). Older patients (OR = 0.95; 95% CI = 0.91-0.99) and participants enrolled in New York/New Jersey (OR = 0.22; 95% CI = 0.07-0.72) were less likely to be tested compared with receiving results before surgery. Those with higher perceived risk (OR = 1.02; 95% CI = 1.00-1.03) were more likely to receive results before surgery than to not be tested. CONCLUSIONS: This study highlights the role of patient-physician communication about GT as well as patient-level factors that predict presurgical GT.


Assuntos
Neoplasias da Mama/genética , Testes Genéticos/estatística & dados numéricos , Adulto , Neoplasias da Mama/epidemiologia , Neoplasias da Mama/cirurgia , Tomada de Decisões , Feminino , Aconselhamento Genético/estatística & dados numéricos , Humanos , Modelos Logísticos , Mid-Atlantic Region/epidemiologia , Pessoa de Meia-Idade , Ensaios Clínicos Controlados Aleatórios como Assunto , Inquéritos e Questionários
8.
Adv Neonatal Care ; 20(2): 161-170, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32224821

RESUMO

BACKGROUND: Limited opportunities for parents to care for their critically ill infant after cardiac surgery can lead to parental unpreparedness and distress. PURPOSE: This project aimed to create and test a bedside visual tool to increase parent partnership in developmentally supportive infant care after cardiac surgery. METHODS: The Care Partnership Pyramid was created by a multidisciplinary team and incorporated feedback from nurses and parents. Three Plan-Do-Study-Act (PDSA) cycles tested its impact on parent partnership in care. Information about developmentally supportive care provided by parents during each 12-hour shift was extracted from nursing documentation. A staff survey evaluated perceptions of the tool and informed modifications. RESULTS: Changes in parent partnership during PDSA 1 did not reach statistical significance. Staff perceived that the tool was generally useful for the patient/family but was sometimes overlooked, prompting its inclusion in the daily goals checklist. For PDSA 2 and 3, parents were more often observed participating in rounds, asking appropriate questions, providing environmental comfort, assisting with the daily care routine, and changing diapers. IMPLICATIONS FOR PRACTICE: Use of a bedside visual tool may lead to increased parent partnership in care for infants after cardiac surgery. IMPLICATIONS FOR RESEARCH: Future projects are needed to examine the impact of bedside care partnership interventions on parent preparedness, family well-being, and infant outcomes.


Assuntos
Recursos Audiovisuais , Cuidadores/educação , Cardiopatias Congênitas/enfermagem , Cardiopatias Congênitas/cirurgia , Cuidado do Lactente/métodos , Terapia Intensiva Neonatal/métodos , Pais/educação , Adulto , Feminino , Humanos , Lactente , Recém-Nascido , Unidades de Terapia Intensiva Pediátrica , Masculino , Mid-Atlantic Region , Equipe de Assistência ao Paciente
9.
J Community Health ; 45(4): 751-760, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-31925604

RESUMO

We utilized a mixed methods approach to assess student attitudes towards tobacco use and campus tobacco policies. Interviews (N = 21), focus groups (N = 2 groups, 4-5 participants each), and an online survey (N = 636) were conducted among a sample of students attending a 4-year, urban, public university in the Mid-Atlantic region of the United States. In interviews and focus groups, students expressed skepticism about a tobacco-free campus policy due to perceived violations of personal rights and challenges with enforcement. Of the sample surveyed, 9.2% and 20.6% had used cigarettes or e-cigarettes within the past 30 days. The majority of students agreed that colleges have a responsibility to adopt tobacco-free policies that reduce the risk of tobacco addiction (62.4%) and ensure smoke-free air to breathe (81.5%). However, more than half (56.3%) also indicated that a policy allowing for designated smoking areas for cigarettes was best for campus, which runs counter to a comprehensive tobacco-free policy. Academic year, gender, and race/ethnicity were significant factors associated with support for tobacco-free policies. Current smokers and vapers were less likely to support tobacco-free policies that reduce the risk of tobacco addiction (OR = 0.3, 95% CI 0.1, 0.7 for smokers; OR = 0.3, 95% CI 0.1, 0.6 for vapers), but not policies that ensure smoke-free air to breathe. E-cigarettes pose a unique obstacle to tobacco-free policies, as students perceived e-cigarettes to be less harmful than cigarettes. To implement a tobacco-free campus policy, students suggested educational campaigns that focus on the potential health benefits of a tobacco-free campus.


Assuntos
Nicotiana , Política Antifumo , Universidades , Adolescente , Adulto , Atitude , Escolaridade , Sistemas Eletrônicos de Liberação de Nicotina , Feminino , Grupos Focais , Humanos , Masculino , Mid-Atlantic Region , Política Pública , Estudantes/estatística & dados numéricos , Inquéritos e Questionários , Produtos do Tabaco , Poluição por Fumaça de Tabaco , Uso de Tabaco , Estados Unidos
10.
Artigo em Inglês | MEDLINE | ID: mdl-31795362

RESUMO

Latina women at risk of hereditary breast and ovarian cancer (HBOC) have lower awareness, knowledge, and use of genetic counseling and testing services (GCT) than non-Latina Whites. Few interventions have been developed to reduce these disparities among at-risk Latinas. This pilot study assessed the impact of a culturally targeted narrative video developed by our team. The study included 40 Latina immigrants living in the United States who were at risk of HBOC, including affected and unaffected women. We assessed pre-post differences in psychosocial outcomes. Participants were 47.35 years old on average (SD = 9.48). Most (70%) were unaffected with cancer, had an annual income of $40,000 or less (65%), an education of High School or less (62.5%), and were uninsured (77.5%). The video significantly enhanced knowledge (p < 0.001), positive attitudes (p < 0.05), anticipatory positive emotions (p < 0.05), and intentions to participate in counseling (p < 0.001). Importantly, the video also significantly reduced negative attitudes (p < 0.05), and attitudinal ambivalence (p < 0.001). The culturally targeted video shows preliminary evidence in improving psychosocial outcomes related to GCT uptake in Latinas at risk for HBOC. This intervention is a promising easily-disseminable strategy to address disparities in GCT utilization.


Assuntos
Síndrome Hereditária de Câncer de Mama e Ovário/psicologia , Hispânico ou Latino/estatística & dados numéricos , Disseminação de Informação , Adulto , Feminino , Síndrome Hereditária de Câncer de Mama e Ovário/terapia , Humanos , América Latina/etnologia , Mid-Atlantic Region , Pessoa de Meia-Idade , Projetos Piloto , Sudeste dos Estados Unidos
11.
Ecotoxicol Environ Saf ; 182: 109387, 2019 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-31302332

RESUMO

A spatiotemporal analysis of benzene was performed in east of the USA and in a representative station in Baltimore County, in order to assess its trend over a 25-year time span between 1993 and 2018. A novel time series analysis technique known as TBATS (an ensemble of Trigonometric seasonal models, Box-Cox transformation, ARMA error plus Trend and Seasonal components) was applied for the first time on an air contaminant. The results demonstrated an annual seasonality and a continuously declining trend in this respect. The success of Reformulated Gasoline Program (RFG), initiated in 1995, was obviously detected in time series data since the daily benzene concentrations reduced to one-sixth of its original level in 1995. In this regard, the respective values of mean absolute scaled error (MASE) were 0.35 and 0.45 for training and test series. Given the observed concentrations of benzene, the hot spot areas in east of the US were identified by spatial analysis, as well. A chronic cancer risk was followed along the study area, by both a deterministic and probabilistic risk assessment (PRA) techniques. It was indicated that children are at higher risk than that of adults. The range of estimated risk values for PRA was higher and varied between 6.45 × 10-6 and 1.68 × 10-4 for adults and between 8.13 × 10-6 and 8.29 × 10-4 for children. According to the findings of PRA, and referring to the threshold level of 1 × 10-4, only 1.2% of the adults and 28.77% of the children were categorized in an immediate risk group.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/análise , Benzeno/análise , Monitoramento Ambiental/métodos , Neoplasias/epidemiologia , Adulto , Criança , Pré-Escolar , Gasolina/análise , Humanos , Masculino , Mid-Atlantic Region/epidemiologia , Probabilidade , Medição de Risco , Fatores de Risco , Sudeste dos Estados Unidos/epidemiologia , Análise Espaço-Temporal
12.
Psychiatr Serv ; 70(10): 940-943, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31185852

RESUMO

OBJECTIVE: Little research has focused on the treatment of adults with substance use disorders in primary care despite the high occurrence, morbidity, and mortality associated with these disorders. METHODS: An electronic survey was administered to primary care providers in a large health system to assess screening and treatment practices and comfort managing opioid use, alcohol use, and depressive disorders. A total of 146 providers completed the survey (32%). RESULTS: Providers were significantly less likely to screen for or treat opioid use disorders and alcohol use disorders, compared with depression. Providers reported feeling significantly less confident, less prepared, less expected to treat, less sure of the appropriateness of treating, and less able to navigate community resources in the treatment of opioid and alcohol use disorders, compared with depression. CONCLUSIONS: Given the preponderance of substance use disorders in primary care, increased attention to equipping primary care providers to treat these conditions is warranted.


Assuntos
Alcoolismo/terapia , Atitude do Pessoal de Saúde , Transtorno Depressivo/terapia , Transtornos Relacionados ao Uso de Opioides/terapia , Atenção Primária à Saúde , Adulto , Alcoolismo/diagnóstico , Transtorno Depressivo/diagnóstico , Feminino , Humanos , Masculino , Programas de Rastreamento , Mid-Atlantic Region , Pessoa de Meia-Idade , Transtornos Relacionados ao Uso de Opioides/diagnóstico , Inquéritos e Questionários
13.
Am J Addict ; 28(4): 303-310, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31069879

RESUMO

BACKGROUND AND OBJECTIVES: E-cigarette use among young people is highly prevalent. Individuals exposed to adverse childhood experiences such as childhood maltreatment (CM) may be at particular risk, as CM has been linked to nicotine dependence. Studies testing the association between CM and e-cigarette use are lacking, including research that examines pathways linking CM to e-cigarette use. METHODS: Using a community sample of young adults (N = 208; ages 18-21), we examined the relationship between CM and e-cigarette use and explored the potential role of impulsivity in linking CM to e-cigarette use via a series of structural equation models controlling for demographic characteristics. RESULTS: CM was significantly associated with lifetime e-cigarette use. Furthermore, CM was associated with negative urgency (NU), whereas NU and sensation seeking were significantly related to lifetime e-cigarette use. NU fully mediated the relationship between CM and lifetime e-cigarette use. CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: Our results suggest that young adults with a history of CM might be vulnerable to e-cigarette use and that NU played a significant role in linking CM to lifetime e-cigarette use. Addressing NU in young adults with a history of CM might be a useful avenue for preventing e-cigarette use in this population. (Am J Addict 2019;28:303-310).


Assuntos
Experiências Adversas da Infância , Maus-Tratos Infantis/psicologia , Comportamento Impulsivo , Vaping/psicologia , Adolescente , Criança , Estudos Transversais , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Mid-Atlantic Region/epidemiologia , Prevalência , Testes Psicológicos , Fatores de Risco , Autorrelato , Vaping/epidemiologia , Adulto Jovem
15.
AORN J ; 107(3): 335-344, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29486085

RESUMO

Surgical team members use fire risk assessment tools to determine the risk of a surgical fire occurring and facilitate communication to reduce risk. The purposes of this quality improvement project were to improve knowledge and awareness of surgical fire risk and increase practitioners' use of a fire risk assessment tool during the surgical safety communication process. We recruited a purposive sample of participants that included all surgical team members of a metropolitan ambulatory surgical center. We based the educational intervention on published evidence and findings of a preintervention knowledge, attitude, and practice (KAP) survey. We assessed knowledge, current practice, and practice intent using a 10-item pretest and posttest, and used a follow-up posttest to assess knowledge retention and practice change. The findings suggest that a brief educational intervention regarding fire risk assessment contributes to improving staff member knowledge and use of prevention strategies.


Assuntos
Incêndios/prevenção & controle , Melhoria de Qualidade , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Procedimentos Cirúrgicos Ambulatórios , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Mid-Atlantic Region , Medição de Risco
16.
Fertil Steril ; 109(2): 266-275, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29338855

RESUMO

OBJECTIVE: To assess the noninferiority of vaginal P (Endometrin) compared with daily intramuscular P for replacement in programmed vitrified-warmed blastocyst transfer cycles and to assess the noninferiority of vaginal P in combination with intramuscular progesterone every third day compared with daily intramuscular P. DESIGN: Three-arm randomized controlled noninferiority study. To enable early recognition of inferiority if present, an a priori interim analysis was planned and completed once ongoing pregnancy data were available for 50% of the total enrollment goal. The results of this interim analysis are presented here. SETTING: Assisted reproduction technology practice. PATIENT(S): Women undergoing transfer of nonbiopsied high quality vitrified-warmed blastocyst(s) in a programmed cycle. INTERVENTION(S): Vitrified-warmed blastocyst transfer with mode of P replacement determined by randomization to either: (1) 50 mg daily intramuscular P only; (2) 200 mg twice daily vaginal Endometrin; or (3) 200 mg twice daily Endometrin plus 50 mg intramuscular P every 3rd day. MAIN OUTCOME MEASURE(S): Live birth. The primary outcome of this interim analysis was ongoing pregnancy. RESULT(S): A total of 645 cycles were randomly assigned to one of the three treatment arms, received at least one dose of P replacement therapy according to this assignment and underwent vitrified-warmed blastocyst transfer. These cycles were included in the intention-to-treat analysis. The study team, including the statistician, were blinded to the identity of the treatment arms, which were randomly labeled "A," "B," and "C" in the dataset. Ongoing pregnancy occurred in 50%, 47%, and 31% of cycles in arms A, B, and C respectively. Although arm C had an rate of positive hCG equivalent to the other two arms, the rate of pregnancy loss for arm C was significantly higher than for either of the two arms, resulting in a more than one-third lower rate of ongoing pregnancy. There were no statistically significant differences for any outcome tested between arms A and B. Results of a per-protocol analysis were nearly identical to those of the intention-to-treat analysis. On completion of these analyses, arm C was revealed to be the vaginal P only arm. CONCLUSION(S): Relative to regimens inclusive of intramuscular P, vaginal-only P replacement for vitrified-warmed blastocyst transfer results in decreased ongoing pregnancy, due to increased miscarriage, and should be avoided. Randomization to the vaginal-only arm was terminated with these findings. This trial is ongoing to assess the noninferiority of the vaginal plus every 3rd day intramuscular P arm compared with daily intramuscular P in terms of live birth. CLINICAL TRIAL REGISTRATION NUMBER: NLM identifier NCT02254577.


Assuntos
Blastocisto/efeitos dos fármacos , Transferência Embrionária , Fármacos para a Fertilidade Feminina/administração & dosagem , Fertilidade/efeitos dos fármacos , Fertilização in vitro , Infertilidade/terapia , Progesterona/administração & dosagem , Administração Intravaginal , Adolescente , Adulto , Esquema de Medicação , Implantação do Embrião/efeitos dos fármacos , Feminino , Fármacos para a Fertilidade Feminina/efeitos adversos , Humanos , Infertilidade/diagnóstico , Infertilidade/fisiopatologia , Injeções Intramusculares , Análise de Intenção de Tratamento , Nascido Vivo , Mid-Atlantic Region , Pessoa de Meia-Idade , Gravidez , Taxa de Gravidez , Progesterona/efeitos adversos , Estudos Prospectivos , Fatores de Tempo , Resultado do Tratamento , Vitrificação , Adulto Jovem
17.
Anesthesiology ; 128(3): 502-510, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-29189209

RESUMO

BACKGROUND: When tracheal intubation is difficult or unachievable before surgery or during an emergent resuscitation, this is a critical safety event. Consensus algorithms and airway devices have been introduced in hopes of reducing such occurrences. However, evidence of improved safety in clinical practice related to their introduction is lacking. Therefore, we selected a large perioperative database spanning 2002 to 2015 to look for changes in annual rates of difficult and failed tracheal intubation. METHODS: Difficult (more than three attempts) and failed (unsuccessful, requiring awakening or surgical tracheostomy) intubation rates in patients 18 yr and older were compared between the early and late periods (pre- vs. post-January 2009) and by annual rate join-point analysis. Primary findings from a large, urban hospital were compared with combined observations from 15 smaller facilities. RESULTS: Analysis of 421,581 procedures identified fourfold reductions in both event rates between the early and late periods (difficult: 6.6 of 1,000 vs. 1.6 of 1,000, P < 0.0001; failed: 0.2 of 1,000 vs. 0.06 of 1,000, P < 0.0001), with join-point analysis identifying two significant change points (2006, P = 0.02; 2010, P = 0.03) including a pre-2006 stable period, a steep drop between 2006 and 2010, and gradual decline after 2010. Data from 15 affiliated practices (442,428 procedures) demonstrated similar reductions. CONCLUSIONS: In this retrospective assessment spanning 14 yr (2002 to 2015), difficult and failed intubation rates by skilled providers declined significantly at both an urban hospital and a network of smaller affiliated practices. Further investigations are required to validate these findings in other data sets and more clearly identify factors associated with their occurrence as clues to future airway management advancements. VISUAL ABSTRACT: An online visual overview is available for this article at http://links.lww.com/ALN/B635.


Assuntos
Serviços de Saúde Comunitária/métodos , Intubação Intratraqueal/estatística & dados numéricos , Assistência Perioperatória/estatística & dados numéricos , Feminino , Humanos , Masculino , Mid-Atlantic Region , Pessoa de Meia-Idade , Estudos Retrospectivos , Tempo
19.
Contemp Nurse ; 53(6): 669-680, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29284341

RESUMO

BACKGROUND: Following adult cardiac surgery, often difficult to detect fluctuations in regional cerebral perfusion can contribute to strokes. Optimal cerebral perfusion remains elusive and traditional monitoring strategies do not consistently identify acute changes. Non-invasive cerebral oximetry may detect perfusion variations. OBJECTIVE: To assess the feasibility of postoperative non-invasive cerebral oximetry monitoring. METHODS: Non-invasive cerebral oximetry was performed on adult aortic valve surgery patients in a cardiac surgical intensive care unit. Monitoring feasibility was assessed using an investigator-developed, data extraction tool. RESULTS: Non-invasive cerebral oximetry was completed in 94% of patients. Sixty percent had values that fell below pre-set ischemic threshold. Nurses reported monitoring was feasible, and they perceived identifying deleterious cerebral perfusion trends may improve patient care. CONCLUSIONS: Prevalence of low cerebral oximetry values underscores the importance of increasing sensitivity of monitoring tools. Further evaluation is required to assess this modality and the role of nurses in optimizing neurocognitive outcomes. Impact statement: Cerebral oximetry monitoring may help identify adult patients at risk of neurological complications after cardiac surgery, and as a consequence initiate definitive therapeutic strategies.


Assuntos
Valva Aórtica/cirurgia , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Monitorização Fisiológica/métodos , Oximetria/métodos , Perfusão/métodos , Cuidados Pós-Operatórios/métodos , Acidente Vascular Cerebral/prevenção & controle , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Mid-Atlantic Region , Pessoa de Meia-Idade
20.
Public Health Rep ; 132(2): 203-209, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28118800

RESUMO

OBJECTIVES: Little is known about the prevalence of human immunodeficiency virus (HIV) testing at community organizations or the organizational characteristics associated with testing. The objective of this study was to describe (1) the prevalence of HIV testing at community organizations serving young people in a mid-Atlantic urban city and (2) the characteristics associated with organizations that provide such testing. METHODS: We conducted telephone or in-person surveys between February 2013 and March 2014 with 51 directors and administrators of community organizations serving young people. We asked whether the organization provided HIV screening or testing, and we collected data on organizational characteristics (eg, setting, client, and staff member characteristics; services offered). We generated frequencies on measures and used Poisson regression analysis to examine the association between testing and organizational characteristics. RESULTS: Of the 51 organizations surveyed, 21 provided HIV testing. Of the 30 organizations that did not provide HIV testing, only 7 had a relationship with programs that did provide it. Characteristics associated with the provision of HIV testing included offering general health services (relative risk [RR] = 4.57; 95% confidence interval [CI], 1.68-12.48; P = .003) and referral services for sexually transmitted infection screening (RR = 5.77; 95% CI, 1.70-19.59; P = .005) and HIV care (RR = 4.78; 95% CI, 1.61-14.21; P = .005), as well as among administrators who perceived their staff members were comfortable talking with young people about sexual health (RR = 3.29; 95% CI, 1.28-8.49; P = .01). CONCLUSIONS: The prevalence of HIV testing provision at organizations serving young people in this mid-Atlantic city was low, and few organizations offered linkages to HIV testing. Strategies are needed to increase the provision of HIV testing at community organizations serving young people, whether through direct or linked approaches.


Assuntos
Serviços de Saúde Comunitária , Infecções por HIV/diagnóstico , Programas de Rastreamento/estatística & dados numéricos , Adolescente , Administradores de Instituições de Saúde , Humanos , Masculino , Mid-Atlantic Region/epidemiologia , Inquéritos e Questionários , População Urbana , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA